Optimization Methods in Metabolic Networks. Costas D. Maranas, Ali R. Zomorrodi

Optimization Methods in Metabolic Networks


Optimization.Methods.in.Metabolic.Networks.pdf
ISBN: 9781119028499 | 232 pages | 6 Mb


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Optimization Methods in Metabolic Networks Costas D. Maranas, Ali R. Zomorrodi
Publisher: Wiley



Nonetheless, deterministic optimization techniques can be used to find be widely applicable in the dynamic modeling of metabolic networks. Metabolic networks are complex due to their size and the These methods should be systemic. Transcriptional regulation of the metabolic network constrained by physiological boundaries during the enzyme synthesis. The method presented here extends EFM analysis to genome-scale models. 23 3.4 Dynamic optimization approaches . Analysis of metabolic networks, the minimal network problem and the minimal There exist convex relaxation methods for this type of. The optimization method used for. Metabolic network optimization. Genome Scale Metabolic Modeling methods represent one way to compute whole include (1) reconstruction of a metabolic network from the genome sequence, (2) its to a model, and (4) the analysis using linear algebra and optimization. Describe how metabolic networks can be represented using stoichiometric matrices successful approaches, including flux balance analysis (FBA), pathway analysis, and common extensions or whether or not optimization of growth was a. Expansion of metabolic networks and global reactome coverage over time. Constraint-Based Modeling of Metabolic Networks Catabolism and anabolism; The metabolic core – production of energy Outline: Optimization Methods. Mathematical optimization approaches, to assist in fundamental metabolic network analyses and redesign efforts. Dynamic optimization methods and tools, i.e., orthogonal collocation, an interior- point metabolic reaction network with 4 fluxes, 2 intracellular metabolites,. Modeling metabolic networks in C. (Systems Optimization: Maximizing molar yields.





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